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Expert Consensus: Lianhua Qingwen Granules is Recommended for Children Infected by Novel Coronavirus during Medical Observation Period

date:2020-02-08

Recently, the Expert Consensus Document on Diagnosis, Treatment and Prevention of Novel Coronavirus Infections in Children (Version I) (hereinafter referred to as the Expert Consensus) was prepared by the National Clinical Medicine Study Center on Respiratory Diseases, the Children's National Medical Center, and the Group of Respiratory Diseases of Society of Pediatrics of Chinese Medical Association. In this Expert Consensus Lianhua Qingwen Granules is recommended for the treatment of such symptoms as weakness, fever, sore throat and dry coughing during the medical observation period for children infected by novel coronavirus.

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The Expert Consensus published this time was developed referencing the Standard Therapy for Novel Coronavirus Pneumonia (Version V, Tentative) published by the National Health Commission and the diagnosis and treatment strategies on the relevant virus infections in children.  Lianhua Qingwen Capsules/Granules are listed as recommended products to be used during the medical observation period in the version IV and the version V of the Standard Therapy for Novel Coronavirus Pneumonia published by the National Health Commission for such symptoms as weakness with fever.   A person who is included into the population of medical observation may not necessarily be definitely suffering from Novel Coronavirus Pneumonia. Persons in this population can be affected by novel coronavirus or be suffering from influenza or common cold.

In the Expert Consensus it is mentioned that most of the children admitted are with relatively mild clinical manifestations and satisfactory outcomes. Most of the cases can recover within 1 to 2 weeks and some of the cases may develop into lower respiratory tract infection.

The therapeutic effects of Lianhua Qingwen for cold and influenza have been proved by large amount of basic and clinical studies. It has been listed as a recommended product in the Standard Therapy for Influenza (2019). And Lianhua Qingwen is also clearly listed as a recommended product for the treatment of influenza corresponds to the syndrome of heat invading the lung in children in the Guideline for Clinical Application of TCM Patent Products · Treatment of Pediatric Diseases.  The syndrome of heat invading the lung in TCM means the case where the heat pathogenic factors are accumulated in the body and invade the lungs. And they are inflammation of different degrees at the lungs. 

The studies performed by the National Key Laboratory of Respiratory Diseases of Guangzhou show that Lianhua Qingwen can reduce the content of inflammatory factors in the lung tissues and alleviate the inflammation of the lung tissues caused by influenza viruses. In the January of 2019, the Random, Double Blind, Placebo Control and Multi-center Clinical Study on Lianhua Qingwen Granules in Treatment of Viral Pneumonia led by Academician Wang Chen was un-blinded formally in the 13 Tier Three Class A hospitals all around the country such as Beijing Hospital of Ministry of Health, Chaoyang Hospital of Capital Medical University, Xuanwu Hospital of Capital Medical University and Traditional Chinese Medicine Hospital of Guangdong Province.  The study results show that Lianhua Qingwen has excellent therapeutic effects in alleviating such clinical symptoms as fever, coughing, expectoration, chest pains, muscular soreness and breathing difficulties of patients suffering from viral pneumonia. So Lianhua Qingwen Capsules/Granules can not only effectively treat influenza but also has excellent therapeutic effects on the inflammation in the lungs as a complication of influenza. 

The famous TCM pediatrician Professor Ma Rong, the former president of the No. 1 Affiliated Hospital of Tianjin University of Traditional Chinese Medicine says that Lianhua Qingwen is mainly composed of two recipes, one is the hemp apricot decoction for the treatment of syndromes caused by exterior pathogenic factors and the other is the Forsythia Powder that has been used for more than two hundred years for the treatment of upper respiratory infection in children. After these two recipes are combined, it is very effective against both fever and coughing. The agastache rugosus in Lianhua Qingwen has the function of removing dampness by means of aromatics and can stop vomiting and diarrhea. It is also very effective in lowering the temperature. Rheum officinale can help the children in bowel relaxing, and then both the fever and the coughing can be effectively alleviated. Rhodiola rosea can play a very important role against hypoxia.

The administration of Lianhua Qingwen Granules is very easy for children who have been included into the medical observation population. We only need to adjust the dosage according to the age and the body weight of the children.