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Tongxinluo Capsule

date:2017-08-31 source:
 

  Read this leaflet carefully, and take this medicine under the doctor or  pharmacists’ direction

  [Drug Name]

  Generic Name: Tongxinluo Capsules

  Chinese Pinyin: Tongxinluo Jiaonang

  [Ingredients] Ginseng, Leech, Scorpion, Red Peony Root, Cicada Slough,  Ground Beetle, Centipede, Sandalwood, Rosewood, Frankincense  Olibanum(processed), Spine Date Seed (stir-baked), Borneol

  [Description] Capsules with brown powdered content; odour, aromatic,  slightly stinking; taste, slightly salty and bitter.

  [Functions and Indications ] To replenish qi and promote blood circulation,  and dredge meridians to kill pain. It is used for angina pectoris in coronary  heart disease caused by a deficiency of heart-qi and blockage of meridians by  stagnated blood with manifestations of constriction, fixed stabbing or colic  pain in the chest, palpitation, spontaneous sweating, shortness of breath,   lassitude, dark purple tongue or ecchymosis, thready and unsmooth pulse or  knotted and intermittent pulse; stroke due to a deficiency of qi and stagnated  blood blocking meridians with manifestations of hemiplegia or numbness of one  side of the body, deviated mouth and tongue and dysphasia.

  [Strength] 0.26g/capsule

  [Administration and Dosage] For oral administration, 2-4 capsules once, 3  times daily.

  [Adverse Reactions] Stomach discomfort may emerge in individual  patient.

  [Contraindication] Contraindicated for patients with hemorrhage, pregnant  women, women during periods, and stroke patients from yin deficiency and fire  hyperactivity.

  [Precautions] Take the medicine after meals if the stomach is  discomfortable after taking it.

  [Pharmacological Actions] Non-clinical pharmacodynamics test showed that:  It can decrease the degree of myocardial ischemia (MI) of canine and dog model  of acute myocardial infarction, diminish the extent of myocardial ischemia (MI)  and improve oxygen-supply and blood-supply, increase coronary blood flow(CBF)  and the function of left ventricle; It can diminish the area of no-reflow after  acute myocardial infarction and reperfusion in the experiment with mini-swine  model and decrease the size of myocardial infarction(MI); It can restrain  proliferation of myocardial collagenous fibers after myocardial infarction in  rats, diminish deposition of collagen protein, decrease the content of  AngiotensinⅡon cardiac muscle (CM), restrain reconstruction of cardiac ventricle  and improve the function of heart; For local cerebral ischemic rat model, it can   diminish the extent of infarction, decrease permeability of cerebral vessels and  brain edema; For global cerebral ischemic in mice, it can mitigate pathological  lesions such as denaturalization and necrosis of nerve cell and less of nissl  body, improve neuroethology, protect ischemic brain tissue, increase the  activity of Superoxide dismutase (SOD) of brain tissue, and reduce the content  of malondialdehyde (MDA); For rat with hyperlipemiat, it can decrease total  cholesterol and low density lipoprotein (LDL), increase high density  lipoprotein(HDL), restrain thrombosis and platelet aggregation in rat’s  body.

  In addition, it is shown by the exploratory study of mechanism of action  for the medicine that: for rat model with cerebral middle artery thrombus, it  can reduce the content of excitatory amino acid and endothelin(ET), restrain the  expression of endothelin gene, for the cerebral ischemic model of rat with  middle cerebral artery thrombus, it can promote the expression of vascular  endothelial growth factor (VEGF), protect the capillary endothelial cell in  brain and promote neogenesis of blood capillary; Improve the endothelium  function of atherosclerosis in rabbit model, and decrease the damage to the   function of endothelium dependent vasodilatation of hypercholesterolemia.  Through improving the expression of endothelial nitricoxide synthase (eNOS) gene  in myocardial ischemic mice, it can increase the activity of endothelial  nitricoxide synthase (eNOS) and the level of nitric oxide (NO) in blood plasma  and tissue; It can decrease the level of total cholesterol (TC) in blood, LDL  cholesterol (LDL-C) as well as endothelin (ET) and increase the level of NO  through restraining the expression of mitogen-activated protein kinase (MAPK)   and vascular intima proliferation after angioplasty in rabbit; For vulnerable  plaques rabbit model, the medicine can play roles in stabilizing the vulnerable  plaque though decreasing intracellular lipid content in plaque as well as  blood-fat and plasma fibrinogen level, increasing the thickness of plaque  fiberous coat and restraining the expression of inflammatory factor; It can  restrain coronary artery spasm (CAS) of mini-swine induced by thrombotonin  (5-HT); Through the above mentioned various functions, the medicine can exert  its effect on protecting heart and brain as well as restraining the formation of   thrombus.

  [Storage] Preserve in tightly closed containers.

  [Package] Aluminium-plastic package, 30 capsules/box.

  [Shelf life] 36 months

  [Executive Standard] Chinese Pharmacopoeia 2010, VolumeⅠ

  [Approval No.] GYZZ Z19980015

  [Manufacturer]

  Company name: Shijiazhuang Yiling Pharmaceutical Co., Ltd.

  Manufacture address: No.238 Tianshan street, New and high development area,  Shijiazhuang, Hebei, China.

  Postcode: 050035

  Tel: 800 8038581 +86 311 85901719 400 8165108

  Fax:+86 311 85901719

  Registration address: No.238 Tianshan street, New and high development  area, Shijiazhuang, Hebei, China.

  URL: http://www.yiling.cn

 

  Shijiazhuang Yiling Pharmaceutical Co., Ltd.


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